The machining of titanium alloys is associated with high temperature levels which result in rapid tool wear and poor surface integrity. To overcome this issue, cooling the cutting zone has emerged as a solution. This study evaluates the impact of different cooling/lubrication techniques on tool life, tool wear, and surface integrity during the milling of Ti-6Al-4V. The results show that using LCO2 and MQL extends tool life by factors of 2.4 and 2.9, respectively, compared to conventional flood cooling. These techniques also improve the surface quality of the machined parts.